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NEC’s AI Supports Doctors To Detect Neoplasia In Barrett’s Esophagus During Endoscopic Procedures

TOKYO, May 28, 2021 – (JCN Newswire) – NEC Corporation
(NEC; TSE: 6701) today announced the development of an AI
technology for supporting doctors to detect neoplasia in
Barrett’s esophagus during endoscopic procedures. This is
the world’s first technology of its kind to comply with the
requirements for CE mark labeling, a European safety, health
and environmental protection standard (1), and is being
released as WISE VISION Endoscopy, where it will soon be
available in Europe to help doctors in the detection of
Barrett’s neoplasia (2).

software is connected to endoscopy processors and
automatically notifies users of potential Barrett’s
neoplasia from images captured during endoscopic

Barrett’s esophagus is a pre-cancerous
condition in which the inner lining of the esophagus is
replaced by a lining that resembles that of the stomach.
Worldwide prevalence of Barrett’s esophagus is 1% of the
entire population but much higher (7%) in patients with
acid-reflux symptoms (3). Patients with Barrett’s esophagus
have 30-40 fold higher risk of developing cancer of the
esophagus as compared to the normal population

However, if this cancer can be detected at an
early stage, then it can be removed through the endoscope
and a patient can be cured. Patients with Barrett’s
esophagus have to undergo regular endoscopy (every 2-3
years) to detect early cancer, but this is still challenging
as the early changes of cancer are very subtle and difficult
to identify. As a result, current recommendations are to
take multiple random biopsies throughout the length of
Barrett’s esophagus to identify any focus of early cancer
(5, 6). However, random biopsies are expensive and time
consuming and are only performed in accordance with official
clinical guidelines by an estimated 30-51% of endoscopists
(7, 8, 9, 10). Consequently, it has been pointed out that up
to 40% of neoplasia may be missed (7) resulting in delayed
cancer diagnosis and poor outcomes for the

To help resolve this issue, NEC collaborated
with Professor Pradeep Bhandari (Portsmouth, UK), Chair of
the European Society of Gastrointestinal Endoscopy (ESGE)
Research Committee, in development of this new technology to
support doctors to detect Barrett’s neoplasia during
examination. WISE VISION Endoscopy has been trained with
more than 1 million Barrett’s esophagus endoscopy images,
together with the knowledge of expert endoscopists, enabling
it to meet the requirements for CE mark labeling. In
developing this solution, NEC applied its face recognition
technology that has been highly evaluated (11) by the
National Institute of Standards and Technology (NIST) in the
United States, and belongs to NEC’s portfolio of
cutting-edge AI technologies, “NEC the WISE.”

clinical evaluation, WISE VISION Endoscopy could find more
than 90% of Barrett’s neoplasia (12). WISE VISION Endoscopy
is expected to significantly reduce the neoplasia miss rate
during endoscopy and improve the outcome for patients with
Barrett’s esophagus all around the world.

The abstract
applying this technology has received the Gut Award from the
British Society of Gastroenterology (BSG), which was
presented in the plenary session of the BSG Campus. It was
also selected one of the best endoscopy abstracts in UEG
Week Virtual 2020 held by United European

“I am delighted that NEC, as one of
the world’s leaders in AI technology, has entered the field
of endoscopy and developed WISE VISION? Endoscopy to detect
and help manage Gastrointestinal neoplasia. Barrett’s
neoplasia can be very flat and easily missed during
endoscopy, despite taking multiple biopsies. I worked with
NEC to develop the Barrett’s neoplasia detection arm of WISE
VISION? Endoscopy and am super impressed by the speed with
which NEC has produced this as the World’s first AI engine
to obtain the CE mark for notifying Barrett’s

“WISE VISION Endoscopy can notify very flat
and subtle lesions and much faster than most endoscopists.
Once the neoplasia is found, this system takes a still image
and transfers it to the top right corner of a screen as a
reference image for endoscopists. It doesn’t stop here, as
it also has a heat map which shows the area of the
AI-predicted neoplasia. WISE VISION? Endoscopy is set to
revolutionize the endoscopic detection and management of
Barrett’s neoplasia in the western world. I’m sure that
clinicians involved in the management of Barrett’s esophagus
are looking forward to the dawn of this new (Wise) era in
Endoscopy,” said Professor Pradeep Bhandari, Chair of the
ESGE Research Committee.


This software can be connected to endoscopes
from three leading endoscope manufacturers (13). By simply
connecting an existing endoscope to a monitor and terminal
equipped with the software, users can start using it
immediately. The system issues sound notifications when a
candidate lesion has been located, and the type and volume
of the notification can be customized at any time according
to user preferences. Moreover, a highly visible user
interface allows intuitive operation, enabling specialists
to smoothly proceed with examinations.

Going forward,
NEC aims to accelerate digital transformation in the medical
field by providing safe and secure products and services,
including AI, to promote a healthy, and sustainable society,
where individuals can thrive from the utilization of
advanced IT technologies.

(1) Source: NEC

(2) “WISE VISION” is a registered
trademark of NEC Corporation in the United States of
America, the European Union and the United

(3) Marques de S? I, Marcos P, Sharma P,
Dinis-Ribeiro M. The global prevalence of Barrett’s
esophagus: A systematic review of the published literature.
United European Gastroenterol J. 2020;8(9):1086-1105.

(4) Sharma P. Clinical
practice. Barrett’s esophagus. N Engl J Med. 2009 Dec
24;361(26):2548-56. doi: 10.1056/NEJMcp0902173. Erratum in:
N Engl J Med. 2010 Apr 15;362(15):1450. PMID:

(5) Weusten B, Bisschops R, Coron E,
Dinis-Ribeiro M, Dumonceau JM, Esteban JM, Hassan C, Pech O,
Repici A, Bergman J, di Pietro M. Endoscopic management of
Barrett’s esophagus: European Society of Gastrointestinal
Endoscopy (ESGE) Position Statement. Endoscopy. 2017
Feb;49(2):191-198. doi: 10.1055/s-0042-122140. Epub 2017 Jan
25. PMID: 28122386.

COMMITTEE, Qumseya B, Sultan S, Bain P, Jamil L, Jacobson B,
Anandasabapathy S, Agrawal D, Buxbaum JL, Fishman DS, Gurudu
SR, Jue TL, Kripalani S, Lee JK, Khashab MA, Naveed M,
Thosani NC, Yang J, DeWitt J, Wani S; ASGE Standards of
Practice Committee Chair. ASGE guideline on screening and
surveillance of Barrett’s esophagus. Gastrointest Endosc.
2019 Sep;90(3):335-359.e2. doi: 10.1016/j.gie.2019.05.012.
PMID: 31439127.

(7) Kariv R, Plesec TP, Goldblum JR,
et al. The Seattle protocol does not more reliably predict
the detection of cancer at the time of esophagectomy than a
less intensive surveillance protocol. Clinical
gastroenterology and hepatology : the official clinical
practice journal of the American Gastroenterological
Association. 2009 Jun;7(6):653-8; quiz 06. PubMed PMID:
19264576. Epub 2009/03/07. eng.

(8) Shaheen NJ, Falk
GW, Iyer PG, Gerson LB, American College of G. ACG Clinical
Guideline: Diagnosis and Management of Barrett’s Esophagus.
Am J Gastroenterol. 2016;

(9) Spechler SJ, Sharma P,
Souza RF, Inadomi JM, Shaheen NJ. American
Gastroenterological Association technical review on the
management of Barrett’s esophagus. Gastroenterology. 2011
Mar;140(3):e18-52; quiz e13.

(10) Abrams JA, Kapel RC,
Lindberg GM, Saboorian MH, Genta RM, Neugut AI, et al.
Adherence to Biopsy Guidelines for Barrett’s Esophagus
Surveillance in the Community Setting in the United States.
Clin Gastroenterol Hepatol [Internet]. 2009 Jul 1 [cited
2018 Nov 16];7(7):736?42.

(11) NEC Face Recognition
Technology Ranks First in NIST Accuracy Testing

Presented at ESGE Days 2021 held by European Society of
Gastrointestinal Endoscopy

(13) Connectivity and
operations have been confirmed with the following

Olympus EVIS LUCERA ELITE Video System
Center CV-290

Olympus EVIS EXERA III Video System
Center CV-190

FUJIFILM ELUXEO video processor

PENTAX Medical OPTIVISTA EPK-i7010 video

PENTAX Medical OPTIVISTA EPK-i7000 video

For More Information


NEC Corporation

NEC Corporation has established itself
as a leader in the integration of IT and network
technologies while promoting the brand statement of
?Orchestrating a brighter world.? NEC enables businesses and
communities to adapt to rapid changes taking place in both
society and the market as it provides for the social values
of safety, security, fairness and efficiency to promote a
more sustainable world where everyone has the chance to
reach their full potential. For more information, visit NEC

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